Protein Details: Gamma-aminobutyric acid receptor subunit gamma-3

Protein ID

ICDB_Pro_0462

Protein Name

Gamma-aminobutyric acid receptor subunit gamma-3

Gene Name

Gabrg3

Organism

Rattus norvegicus (Rat)

Length

467 amino acids

AlphaFoldDB

AF-P28473-F1-model_v4.pdb

Function

Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA); a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels; also named GABA(A) receptors (GABAAR); consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA; GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient.

Sequence

MAAKLLLLLCLFSGLHARSRRVEEDDSEDSPSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDAHACPLTFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTTLGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTIRKKKTSLLHPDSTRWIPDRISLQAPSNYSLLDMRPPPPVMITLNNSMYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRRGRIHIDVSELDSYSRVFFPTSFLLFNLVYWVGYLYL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in brain

DOI ID

10.1073/pnas.89.4.1433; 10.1016/0014-5793(91)81184-a; 10.1124/mol.56.3.598

RefSeq

NP_077346.3